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Research in the Waschek laboratory centers primarily on a class of molecules called neuropeptides - short peptides that classically act in the central and peripheral nervous systems to control a wide variety of behaviors and neurological processes.

Much of the laboratories efforts have focused on two structurally-related peptides that are widely expressed in neurons, vasoactive intestinal peptide (VIP), and pituitary adenylyl cyclase activating peptide (PACAP). These neuropeptides are rather unusual because they function not only as neurotransmitters, regulating processes such as circadian rhythms, cognition, and stress responses, but also as immunomodulators and as factors involved in growth and repair.

Most Recent Publication

Seiriki Kaoru , Kasai Atsushi , Hashimoto Takeshi , Schulze Wiebke , Niu Misaki , Yamaguchi Shun , Nakazawa Takanobu , Inoue Ken-Ichi , Uezono Shiori , Takada Masahiko , Naka Yuichiro , Igarashi Hisato , Tanuma Masato , Waschek James A., Ago Yukio , Tanaka Kenji F., Hayata-Takano Atsuko , Nagayasu Kazuki , Shintani Norihito , Hashimoto Ryota , Kunii Yasuto , Hino Mizuki , Matsumoto Junya , Yabe Hirooki , Nagai Takeharu , Fujita Katsumasa , Matsuda Toshio , Takuma Kazuhiro , Baba Akemichi , Hashimoto Hitoshi High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates. Neuron 94 (2017) 1085-1100.e6