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Research in the Waschek laboratory centers primarily on a class of molecules called neuropeptides - short peptides that classically act in the central and peripheral nervous systems to control a wide variety of behaviors and neurological processes.

Much of the laboratories efforts have focused on two structurally-related peptides that are widely expressed in neurons, vasoactive intestinal peptide (VIP), and pituitary adenylyl cyclase activating peptide (PACAP). These neuropeptides are rather unusual because they function not only as neurotransmitters, regulating processes such as circadian rhythms, cognition, and stress responses, but also as immunomodulators and as factors involved in growth and repair.

Most Recent Publication

Abad Catalina , Jayaram Bhavaani , Becquet Laurine , Wang Yuki , O'Dorisio Sue , Waschek James A., Tan Yossan-Var VPAC1 receptor (Vipr1)-deficient mice exhibit ameliorated experimental autoimmune encephalomyelitis, with specific deficits in the effector stage. J Neuroinflammation 13 (2016) 169