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Administration
Jean de Vellis
This Core provides overall management and organizational support to the Center, including grant submissions and management, financial and personnel management, recruiting, compliance, general laboratory technical services, planning and managing research retreats, symposia and seminars.
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Animal Models
Ellen Carpenter and Michael Levine
The Animal Models Core will provide the following primary services: animal breeding and maintenance, genotyping, biohazardous materials usage and behavioral assessment.
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Cell Models
Jean de Vellis
The discovery that the adolescent and even adult CNS possesses the potential to regenerate via multi-potent stem cells, has given rise to increasing interest in studying neural stem cells either to understand pathogenesis in neurodegenerative diseases in animal models or as potential therapeutic tools for degenerative diseases. The purpose of Cell Models core is to fulfill the need of incorporating new technology aimed at the study of the restoration of CNS function.
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Cellular Imaging
Jean de Vellis
The Cellular Imaging Core focuses on providing researchers with the ability to obtain high quality imaging data using state-of-the-art microscopy instruments. The Core also aims to provide information about imaging, image processing and cell/tissue processing for imaging.
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Education
The Education Core is directed by Drs. Susan Bookheimer and James Waschek. It is designed to foster interactions and enrich the research and training environment of IDDRC faculty, trainees, and other personnel through annual retreats, minisymposia, invited speakers, and core-based technology workshops.
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Electrophysiological Assessment
Michael Levine and Carlos Cepeda
Electrophysiological assessments will consist of experiments performed in brain slices, acutely isolated neurons or cultures providing a functional analysis of changes in neurons, local circuits and microcircuits induced primarily by genetic alterations in cellular, mouse or rat models.
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Epigenetics
Yi Sun
The Epigenetics Core provides genome-wide DNA methylation, histone modification, and chromatin immunoprecipitation (ChIP) services, along with targeted gene region analysis and validation, to support wide range of projects within the UCLA IDDRC.
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Immunology
James Waschek
The Immunology core is intended to assist in both classical and new generation multicolor flow cytometry/FACS and in specialized immunohistochemical methods necessary to examine immune responses (microglia and subsequent astrocyte activation, invasion of macrophages and T helper subsets and other immune cells) in CNS pathology. This Core is intended to be applicable to both rodent models and in some cases human studies.
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NeurogenomIcs/Bioinformatics
Daniel Geschwind
The NeurogenomIcs/Bioinformatics core focuses on the application of genome-level analyses in neuroscientific investigation, most based on microarray related technologies, but also supporting a burgeoning use of next-generation sequencing-based approaches, such as RNA sequencing (RNA–seq) and ChIP–seq.
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Stem Cells
Yi Sun and Harley Kornblum
IDDRC investigators are studying developmental and pathological processes that contribute to intellectual disabilities. The goal of the Stem Cells Core is to provide investigators with high quality cellular tools to enhance these studies and to contribute to the translational mission of the IDDRC.
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Translational Core for Human Phenotyping & Imaging
Susan Bookheimer and James McCracken
The Translational Core for Human Phenotyping & Imaging provides two broad categories of services: 1) Pediatric neuroimaging services: behavioral desensitization protocols will be performed prior to scanning; MRI scan operation by personnel trained in pediatric imaging; experimental design and MRI pulse sequence protocol development consultation services, and imaging processing services; 2) Human phenotyping and protocol development: consultation for phenotyping, behavioral assessment of children with disabilities including pediatric assessment services and outcome measures for intervention, protocol development, and clinical trial consultation.
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